Accelerator mass spectrometry in biomedical research
نویسندگان
چکیده
منابع مشابه
Accelerator mass spectrometry for biomedical research.
Accelerator mass spectrometry (AMS) is the most sensitive method for detecting and quantifying rare long-lived isotopes with high precision. In this chapter, we review the principles underlying AMS-based biomedical studies, focusing on important practical considerations and experimental procedures needed for the detection and quantitation of (14)C- and (3)H-labeled compounds in various experime...
متن کاملBiomedical accelerator mass spectrometry: recent applications in metabolism and pharmacokinetics.
BACKGROUND Accelerator mass spectrometry (AMS) is a sensitive isotope ratio technique used in drug development that allows for small levels of 14C-drug to be administered to humans, thereby removing regulatory hurdles associated with radiotracer studies. AMS uses innovative study designs to obtain pharmacokinetic and metabolism data. OBJECTIVE This review addresses the metabolism and pharmaco...
متن کاملMass Spectrometry Applications in Biomedical Research
Copyright © 2015 Fa-Yun Che et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. We are so happy and excited to see our special issue published. With the tremendous advances of modern mass spectrometry (MS) techniques, MS has be...
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Accelerator Mass Spectrometry is a mass spectrometric method of detecting long-lived radioisotopes without regard to their decay products or half-life. The technique is normally applied to geochronology, but is also available for bioanalytical tracing. AMS detects isotope concentrations to parts per quadrillion, quantifying labeled biochemicals to attomole levels in milligram-sized samples. Its...
متن کاملAccelerator Mass Spectrometry at Vera
The Vienna Environmental Research Accelerator (VERA) is a dedicated facility for accelerator mass spectrometry (AMS), operated at the University of Vienna since 1996. The principle of AMS with VERA and the advantage of measuring long-lived radioisotopes by atom counting (AMS) rather than decay counting (ß decay) is described. A brief overview on AMS applications is also presented.
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ژورنال
عنوان ژورنال: Nuclear Instruments and Methods in Physics Research Section B: Beam Interactions with Materials and Atoms
سال: 1994
ISSN: 0168-583X
DOI: 10.1016/0168-583x(94)96052-6